NSAIDs Market Type, Development Trends and Market Threats Forecast by 2022

Global Nonsteroidal Anti-inflammatory Drugs (NSAIDs) Market is expected to grow at a higher CAGR in the forecast period. NSAIDs (nonsteroidal anti-inflammatory drugs) decrease inflammation but are not related to steroids that also reduce inflammation. NSAIDs work by plummeting the production of prostaglandins. NSAIDs are a drug class that groups together drugs that provide analgesic (pain killing) and antipyretic (fever-reducing) effects, and, in superior doses, anti-inflammatory effects. Prostaglandins are chemicals that promote inflammation, pain, and fever. They also protect the lining of the stomach and intestines from the damaging effects of acid, encourage blood clotting by activating blood platelets, and promote normal function of the kidneys.

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The enzymes that produce prostaglandins are called cyclooxygenases (COX). There are two types of COX enzymes, viz COX-1 and COX-2. Both the enzymes produce prostaglandins that promote inflammation, pain, and fever. However, only COX-1 produces prostaglandins that activate platelets, protect the stomach and intestinal lining.NSAIDs block COX enzymes, and reduce production of prostaglandins. Therefore, inflammation, pain, and fever are reduced. Since the prostaglandins that protect the stomach and promote blood clotting are also reduced, NSAIDs that block both COX-1 and COX-2 can cause ulcers in the stomach and intestines, and increase the risk of bleeding.

Aspirin, the only NSAID able to irrevocably inhibit COX-1, is also indicated for inhibition of platelet aggregation. This is useful for the management of arterial thrombosis and prevention of adverse cardiovascular events. Aspirin inhibits platelet aggregation by inhibiting the action of thromboxane A2.In general, the NSAIDs inhibit both - COX-1 and COX-2. Most NSAIDs are mainly COX-1 selective (e.g., aspirin, ketoprofen, indomethacin, piroxicam, sulindac). Others are measured slightly selective for COX-1 (eg, ibuprofen, naproxen, diclofenac) and the others may be considered slightly selective for COX-2 (eg, etodolac, nabumetone, and meloxicam).

The mechanism of action of celecoxib and rofecoxib is primarily selective inhibition of COX-2; at therapeutic concentrations, the COX-1 isoenzyme is not inhibited thus GI toxicity may be decreased.Other mechanisms that may supply to NSAID anti-inflammatory activity include the reduction of superoxide radicals, induction of apoptosis, inhibition of adhesion molecule expression, reduce of nitric oxide synthase, reduce of proinflammatory cytokine levels (tumor necrosis factor-a, interleukin-1), modification of lymphocyte activity, and alteration of cellular membrane functions. Central analgesic activity has been established in animal pain models by some NSAIDs such as diclofenac, ibuprofen, indomethacin, and ketoprofen.

This could be because of the interference of prostaglandin (PGE1, F2 and F2a) mediated pain formation or with transmitters or modulators in the nociceptive system. The other proposals include the central action mediated by opioid peptides, inhibition of serotonin release, or inhibition of excitatory amino acids or N-methyl-D-aspartate receptors.

NSAIDs are mainly effective against the type of pain in which PGs sensitize pain receptors (inflammation and tissues) including the pain of arthritis, bursitis, pain of muscular andmvascula origin and dysmenorrhea. The efficiency of these agents against headache may result from their aptitude to inhibit PG-mediated cerebral vascular vasodilation.

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NSAIDs are useful in the management of post-operative dental pain following invasive dental events such as dental extraction. When not contra-indicated they are favored over the use of paracetamol without help due to the anti-inflammatory result they give. When used in mixture with paracetamol the analgesic effect has been established to be enhanced.

NSAIDs Market is segmented by Product Type into Aspirin, Ibuprofen, Naproxen; Nabumetone.NSAIDs Market is segmented by Application into Back Pain treatment, Osteoarthritis treatment, and the other disease treatment. Geographically, the NSAIDs market spans North America, Europe, China, Japan, and Southeast Asia, India.The Key Players in the NSAIDs market include Bayer (DE), Nova cap (FR), Abbott, Pfizer Inc, Geri-Care Pharmaceuticals, Perrigo Company, Kopran Ltd., Merck Sharp & Dohme Corp., Sun Pharmaceutical Industries Ltd, GlaxoSmithKline, Reddy Pharmaceuticals Ltd, Johnson & Johnson.